Tetramer‐based identification of naïve antigen‐specific B cells within a polyclonal repertoire
نویسندگان
چکیده
منابع مشابه
Identification of a polyclonal B-cell activator in Plasmodium falciparum.
Polyclonal B-cell activation and hypergammaglobulinemia are prominent features of human malaria. We report here that Plasmodium falciparum-infected erythrocytes directly adhere to and activate peripheral blood B cells from nonimmune donors. The infected erythrocytes employ the cysteine-rich interdomain region 1alpha (CIDR1alpha) of P. falciparum erythrocyte membrane protein 1 (PfEMP1) to intera...
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متن کاملPersistent polyclonal B-cell lymphocytosis.
We document a case of persistent lymphocytosis in which the characteristic binucleated circulating lymphocytes were shown immunologically to be polyclonal B-cells. Cytogenetic and molecular studies failed to show a clonal population. A review of the literature on this rare condition, persistent polyclonal B-cell lymphocytosis, highlights an association with the female sex, HLA-DR7 antigen, smok...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2018
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.201747447